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1

Structure of the Shigella T3SS effector IpaH defines a new class of E3 ubiquitin ligases

Singer, Alexander U, Rohde, John R, Lam, Robert, Skarina, Tatiana, Kagan, Olga, DiLeo, Rosa, Chirgadze, Nickolay Y, Cuff, Marianne E, Joachimiak, Andrzej, Tyers, Mike

Journal:

Nature Structural and Molecular Biology

Year:

2008

Language:

english

File:

PDF, 1.25 MB

english, 2008

2

Real-time tracking of complex ubiquitination cascades using a fluorescent confocal on-bead assay

Koszela, Joanna, Pham, Nhan T., Evans, David, Mann, Stefan, Perez-Pi, Irene, Shave, Steven, Ceccarelli, Derek F. J., Sicheri, Frank, Tyers, Mike, Auer, Manfred

Journal:

Year:

2018

Language:

english

File:

PDF, 1.43 MB

english, 2018

3

The p38/HOG stress-activated protein kinase network couples growth to division in Candida albicans

Sellam, Adnane, Chaillot, Julien, Mallick, Jaideep, Tebbji, Faiza, Richard Albert, Julien, Cook, Michael A., Tyers, Mike, Butler, Geraldine

Journal:

Year:

2019

Language:

english

File:

PDF, 7.83 MB

english, 2019

4

Deregulation ofCLN1 andCLN2 in theSaccharomyces cerevisiae whi2 Mutant

RADCLIFFE, PIPPA, TREVETHICK, JANET, TYERS, MIKE, SUDBERY, PETER

Journal:

Year:

1997

Language:

english

File:

PDF, 144 KB

english, 1997

5

From large networks to small molecules

Jeffrey R Sharom, David S Bellows, Mike Tyers

Journal:

Current Opinion in Chemical Biology

Year:

2004

Language:

english

File:

PDF, 2.08 MB

english, 2004

6

Benchmarking of the 2010 BioCreative Challenge III text-mining competition by the BioGRID and MINT interaction databases

Andrew Chatr-aryamontri, Andrew Winter, Livia Perfetto, Leonardo Briganti, Luana Licata, Marta Iannuccelli, Luisa Castagnoli, Gianni Cesareni, Mike Tyers

Journal:

BMC Bioinformatics

Year:

2011

Language:

english

File:

PDF, 379 KB

english, 2011

7

Broadening the horizon – level 2.5 of the HUPO-PSI format for molecular interactions

Samuel Kerrien, Sandra Orchard, Luisa Montecchi-Palazzi, Bruno Aranda, Antony F Quinn, Nisha Vinod, Gary D Bader, Ioannis Xenarios, Jérôme Wojcik, David Sherman, Mike Tyers, John J Salama, Susan Moore

Journal:

Year:

2007

Language:

english

File:

PDF, 1.53 MB

english, 2007

8

Size control goes global

Mike Cook, Mike Tyers

Journal:

Current Opinion in Biotechnology

Year:

2007

Language:

english

File:

PDF, 590 KB

english, 2007

9

10.1038/25774

Futcher, Bruce, Tyers, Mike, Schneider, Brandt L., Patton, E. Elizabeth, Lanker, Stefan, Mendenhall, Michael D., Wittenberg, Curt

Journal:

Year:

1998

Language:

english

File:

PDF, 319 KB

english, 1998

10

10.1038/35060126

Ganoth, Dvora, Bornstein, Gil, Ko, Tun K., Larsen, Brett, Tyers, Mike, Pagano, Michele, Hershko, Avram

Journal:

Nature Cell Biology

Year:

2001

Language:

english

File:

PDF, 471 KB

english, 2001

11

Cell cycle: Archipelago of destruction

Schwab, Michael, Tyers, Mike

Journal:

Year:

2001

Language:

english

File:

PDF, 153 KB

english, 2001

12

Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication

Nash, Piers, Tang, Xiaojing, Orlicky, Stephen, Chen, Qinghua, Gertler, Frank B., Mendenhall, Michael D., Sicheri, Frank, Pawson, Tony, Tyers, Mike

Journal:

Year:

2001

Language:

english

File:

PDF, 446 KB

english, 2001

13

Inhibition of Gl cyclin activity by the Ras/cAMP pathway in yeast

Tokiwa, George, Tyers, Mike, Volpe, Tom, Futcher, Bruce

Journal:

Year:

1994

File:

PDF, 580 KB

1994

14

From genomics to proteomics

Tyers, Mike, Mann, Matthias

Journal:

Year:

2003

Language:

english

File:

PDF, 770 KB

english, 2003

15

The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase

Pintard, Lionel, Willis, John H., Willems, Andrew, Johnson, Jacque-Lynne F., Srayko, Martin, Kurz, Thimo, Glaser, Sarah, Mains, Paul E., Tyers, Mike, Bowerman, Bruce

Journal:

Year:

2003

Language:

english

File:

PDF, 503 KB

english, 2003

16

An allosteric inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase

Orlicky, Stephen, Tang, Xiaojing, Neduva, Victor, Elowe, Nadine, Brown, Eric D, Sicheri, Frank, Tyers, Mike

Journal:

Nature Biotechnology

Year:

2010

Language:

english

File:

PDF, 1.11 MB

english, 2010

17

A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans

Burns, Andrew R, Wallace, Iain M, Wildenhain, Jan, Tyers, Mike, Giaever, Guri, Bader, Gary D, Nislow, Corey, Cutler, Sean R, Roy, Peter J

Journal:

Nature Chemical Biology

Year:

2010

Language:

english

File:

PDF, 872 KB

english, 2010

18

Chemical genetics reveals a complex functional ground state of neural stem cells

Diamandis, Phedias, Wildenhain, Jan, Clarke, Ian D, Sacher, Adrian G, Graham, Jeremy, Bellows, David S, Ling, Erick K M, Ward, Ryan J, Jamieson, Leanne G, Tyers, Mike

Journal:

Nature Chemical Biology

Year:

2007

Language:

english

File:

PDF, 634 KB

english, 2007

19

SAINT: probabilistic scoring of affinity purification–mass spectrometry data

Choi, Hyungwon, Larsen, Brett, Lin, Zhen-Yuan, Breitkreutz, Ashton, Mellacheruvu, Dattatreya, Fermin, Damian, Qin, Zhaohui S, Tyers, Mike, Gingras, Anne-Claude, Nesvizhskii, Alexey I

Journal:

Year:

2010

Language:

english

File:

PDF, 666 KB

english, 2010

20

Inducible dissociation of SCFMet30 ubiquitin ligase mediates a rapid transcriptional response to cadmium

Barbey, Régine, Baudouin-Cornu, Peggy, Lee, Traci A, Rouillon, Astrid, Zarzov, Patrick, Tyers, Mike, Thomas, Dominique

Journal:

The EMBO Journal

Year:

2005

Language:

english

File:

PDF, 598 KB

english, 2005

21

Feedback-regulated degradation of the transcriptional activator Met4 is triggered by the SCFMet30 complex

Rouillon, Astrid, Barbey, Régine, Patton, E.Elizabeth, Tyers, Mike, Thomas, Dominique

Journal:

The EMBO Journal

Year:

2000

Language:

english

File:

PDF, 1.01 MB

english, 2000

22

Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy

Ejim, Linda, Farha, Maya A, Falconer, Shannon B, Wildenhain, Jan, Coombes, Brian K, Tyers, Mike, Brown, Eric D, Wright, Gerard D

Journal:

Nature Chemical Biology

Year:

2011

Language:

english

File:

PDF, 460 KB

english, 2011

23

A hitchhiker's guide to the cullin ubiquitin ligases: SCF and its kin

Andrew R. Willems, Michael Schwab, Mike Tyers

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2004

Language:

english

File:

PDF, 1.59 MB

english, 2004

24

Cell cycle goes global

Journal:

Current Opinion in Cell Biology

Year:

2004

Language:

english

File:

PDF, 274 KB

english, 2004

25

Cell division, growth and death: The cellular trinity of division, growth and death

Scott Kaufmann, Mike Tyers

Journal:

Current Opinion in Cell Biology

Year:

2005

Language:

english

File:

PDF, 65 KB

english, 2005

26

Life and death decisions

Angelika Amon, Mike Tyers

Journal:

Current Opinion in Cell Biology

Year:

2009

Language:

english

File:

PDF, 92 KB

english, 2009

27

Mathematical Modeling Suggests Cooperative Interactions between a Disordered Polyvalent Ligand and a Single Receptor Site

Peter Klein, Tony Pawson, Mike Tyers

Journal:

Current Biology

Year:

2003

Language:

english

File:

PDF, 295 KB

english, 2003

28

Cellular Differentiation: The Violin Strikes up Another Tune

Michael A Cook, Mike Tyers

Journal:

Current Biology

Year:

2004

Language:

english

File:

PDF, 134 KB

english, 2004

29

How Cells Coordinate Growth and Division

Paul Jorgensen, Mike Tyers

Journal:

Current Biology

Year:

2004

Language:

english

File:

PDF, 1.89 MB

english, 2004

30

Structure/Function Implications in a Dynamic Complex of the Intrinsically Disordered Sic1 with the Cdc4 Subunit of an SCF Ubiquitin Ligase

Tanja Mittag, Joseph Marsh, Alexander Grishaev, Stephen Orlicky, Hong Lin, Frank Sicheri, Mike Tyers, Julie D. Forman-Kay

Journal:

Year:

2010

Language:

english

File:

PDF, 1.26 MB

english, 2010

31

The F-box: a new motif for ubiquitin dependent proteolysis in cell cycle regulation and signal transduction

Karen L. Craig, Mike Tyers

Journal:

Progress in Biophysics and Molecular Biology

Year:

1999

Language:

english

File:

PDF, 366 KB

english, 1999

32

Combinatorial control in ubiquitin-dependent proteolysis: don't Skp the F-box hypothesis

E.Elizabeth Patton, Andrew R Willems, Mike Tyers

Journal:

Trends in Genetics

Year:

1998

Language:

english

File:

PDF, 1.89 MB

english, 1998

33

Transcriptional regulation: Kamikaze activators

Dominique Thomas, Mike Tyers

Journal:

Current Biology

Year:

2000

Language:

english

File:

PDF, 74 KB

english, 2000

34

Deletion of the Cul1 gene in mice causes arrest in early embryogenesis and accumulation of cyclin E

Yisong Wang, Sonya Penfold, Xiaojing Tang, Naka Hattori, Paul Riley, J.Wade Harper, James C. Cross, Mike Tyers

Journal:

Current Biology

Year:

1999

Language:

english

File:

PDF, 142 KB

english, 1999

35

Fission yeast Clp1p phosphatase regulates G2/M transition and coordination of cytokinesis with cell cycle progression

Susanne Trautmann, Benjamin A. Wolfe, Paul Jorgensen, Mike Tyers, Kathleen L. Gould, Dannel McCollum

Journal:

Current Biology

Year:

2001

Language:

english

File:

PDF, 674 KB

english, 2001

36

MAPK specificity in the yeast pheromone response independent of transcriptional activation

Ashton Breitkreutz, Lorrie Boucher, Mike Tyers

Journal:

Current Biology

Year:

2001

Language:

english

File:

PDF, 428 KB

english, 2001

37

Regulation of the mating pheromone and invasive growth responses in yeast by two MAP kinase substrates

Kerry Tedford, Sammy Kim, Danne Sa, Ken Stevens, Mike Tyers

Journal:

Current Biology

Year:

1997

Language:

english

File:

PDF, 278 KB

english, 1997

38

MAPK signaling specificity: it takes two to tango

Ashton Breitkreutz, Mike Tyers

Journal:

Trends in Cell Biology

Year:

2002

Language:

english

File:

PDF, 117 KB

english, 2002

39

Functional genomics and proteomics: charting a multidimensional map of the yeast cell

Gary D. Bader, Adrian Heilbut, Brenda Andrews, Mike Tyers, Timothy Hughes, Charles Boone

Journal:

Trends in Cell Biology

Year:

2003

Language:

english

File:

PDF, 3.99 MB

english, 2003

40

CDK Activity Antagonizes Whi5, an Inhibitor of G1/S Transcription in Yeast

Michael Costanzo, Joy L Nishikawa, Xiaojing Tang, Jonathan S Millman, Oliver Schub, Kevin Breitkreuz, Danielle Dewar, Ivan Rupes, Brenda Andrews, Mike Tyers

Journal:

Year:

2004

Language:

english

File:

PDF, 819 KB

english, 2004

41

A Mechanism for Cell-Cycle Regulation of MAP Kinase Signaling in a Yeast Differentiation Pathway

Shelly C. Strickfaden, Matthew J. Winters, Giora Ben-Ari, Rachel E. Lamson, Mike Tyers, Peter M. Pryciak

Journal:

Year:

2007

Language:

english

File:

PDF, 1.36 MB

english, 2007

42

Suprafacial Orientation of the SCFCdc4 Dimer Accommodates Multiple Geometries for Substrate Ubiquitination

Xiaojing Tang, Stephen Orlicky, Zhenyuan Lin, Andrew Willems, Dante Neculai, Derek Ceccarelli, Frank Mercurio, Brian H. Shilton, Frank Sicheri, Mike Tyers

Journal:

Year:

2007

Language:

english

File:

PDF, 1.51 MB

english, 2007

43

Cell Size Control: Governed by a Spatial Gradient

Ricardo Almeida, Mike Tyers

Journal:

Developmental Cell

Year:

2009

Language:

english

File:

PDF, 202 KB

english, 2009

44

Structural and Functional Analysis of Saccharomyces cerevisiae Mob1

Serge Mrkobrada, Lorrie Boucher, Derek F.J. Ceccarelli, Mike Tyers, Frank Sicheri

Journal:

Journal of Molecular Biology

Year:

2006

Language:

english

File:

PDF, 1.14 MB

english, 2006

45

New drugs for brain tumors? Insights from chemical probing of neural stem cells

Phedias Diamandis, Adrian G. Sacher, Mike Tyers, Peter B. Dirks

Journal:

Medical Hypotheses

Year:

2009

Language:

english

File:

PDF, 283 KB

english, 2009

46

Growth and development: The whole picture begins to emerge

Mike Tyers, Mark J Buttner

Journal:

Current Opinion in Microbiology

Year:

2004

Language:

english

File:

PDF, 80 KB

english, 2004

47

Dcn1 Functions as a Scaffold-Type E3 Ligase for Cullin Neddylation

Thimo Kurz, Yang-Chieh Chou, Andrew R. Willems, Nathalie Meyer-Schaller, Marie-Lyn Hecht, Mike Tyers, Matthias Peter, Frank Sicheri

Journal:

Year:

2008

Language:

english

File:

PDF, 1.90 MB

english, 2008

48

F-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex

Dorota Skowyra, Karen L Craig, Mike Tyers, Stephen J Elledge, J.Wade Harper

Journal:

Year:

1997

Language:

english

File:

PDF, 397 KB

english, 1997

49

Intracellular Proteolysis—Garbage Disposal? Rubbish!: Ubiquitin and the Biology of the Cell Edited by Jan-Michael Peters, J. Robin Harris, and Daniel Finley New York: Plenum Press (1998). 472 pp. $115.00; Intracellular Protein Degradation Advances in Molecular and Cellular Biology, Volume 27 Edited by A. Jennifer Rivett and E. Edward Bittar Stamford, CT: JAI Press Inc. (1998). 301 pp. $128.50

Journal:

Year:

1999

Language:

english

File:

PDF, 49 KB

english, 1999

50

Structural Basis for Phosphodependent Substrate Selection and Orientation by the SCFCdc4 Ubiquitin Ligase

Stephen Orlicky, Xiaojing Tang, Andrew Willems, Mike Tyers, Frank Sicheri

Journal:

Year:

2003

Language:

english

File:

PDF, 944 KB

english, 2003